Bezesteni Larissa is a large rectangular building dimensions 30 on 20 meters built of large stones and bricks. Are even cases that marble architectural parts of the ancient temple of Athena Polias that existed in the area is built therein. On each side there was an entrance that led inside.
The Museum is constructed at the Mezourlo hill, in an area of 5 acres planted with pines, which was ceded by the Municipality of Larissa to the Ministry of Culture. The arrangement of the permanent exhibition is based on axes of chronological narration, geographic distribution and special subjects.
Larissa, sometimes written Larisa on ancient coins and inscriptions, is near the site of the Homeric Argissa. It appears in early times, when Thessaly was mainly governed by a few aristocratic families, as an important city under the rule of the Aleuadae, whose authority extended over the whole district of Pelasgiotis.