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Are ground glass nodules always cancerous?

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"1. Multiple (at least 35) bilateral ground glass nodules and opacities, ranging in size from 0. 3 cm to 1 x 1. 6 cm, in all lobes. A couple more solid-appearing 0. 3 cm left lower lobe micrododules are present. 1 x 1. 6 cm groundglass opacity in right lower lobe is amenable to CT-guided biopsy. read more

The advent of computed tomography screening for lung cancer will increase the incidence of ground-glass opacity (GGO) nodules detected and referred for diagnostic evaluation and management. GGO nodules remain a diagnostic challenge; therefore, a more systematic approach is necessary to ensure correct diagnosis and optimal management. read more

3) Even if your pure GGN nodules <10mm are malignant, there is a 95% chance that it is either AAH (think mole type of lesion but not cancer yet) or AIS (new definition of BAC) which has a 100% 5 year survival rate among patients that had their pure GGNs resected (link below summarizes all of the research on this over the last 10 years--from Japan where GGNs are quite common). read more

"1. Multiple (at least 35) bilateral ground glass nodules and opacities, ranging in size from 0.3 cm to 1 x 1.6 cm, in all lobes. A couple more solid-appearing 0.3 cm left lower lobe micrododules are present. 1 x 1.6 cm groundglass opacity in right lower lobe is amenable to CT-guided biopsy. read more

In one of these (the Pan-American Early Detection of Lung Cancer Study (PanCan,) 7008 nodules were found among 1871 people. Of these 102 were cancerous. In the other (a British Columbia Cancer Agency (BCCA) study,) 5001 nodules were found in 1090 people, with 42 being malignant. read more

Nodules that demonstrate ground-glass opacity (GGO) on CT are particularly challenging on account of their malignant potential and heterogeneous characteristics.[4] This review focuses on the radiologic and pathologic features of GGO nodules, along with the clinical management of these lesions. read more

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