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Are proteins acidic or basic?

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Acidic and Basic Amino Acids. There are three amino acids that have basic side chains at neutral pH. These are arginine (Arg), lysine (Lys), and histidine (His). Their side chains contain nitrogen and resemble ammonia, which is a base. read more

If it contains more amino acids that are acidic ( like aspartic or glutamic acid), then it could be acidic. If it has more amino acids that are basic ( like arginine or lysine ) then the protein could be basic. If the number of acidic and basic amino acids are balanced, then the protein will be neutral in charge. read more

Two amino acids have acidic side chains at neutral pH. These are aspartic acid or aspartate (Asp) and glutamic acid or glutamate (Glu). Their side chains have carboxylic acid groups whose pKa's are low enough to lose protons, becoming negatively charged in the process. read more

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