Are the first weeks on antidepressants the worst?

Since most antidepressant side effects tend to stick around or get worse, and the side effects and withdrawal syndromes can last indefinitely even after discontinuing an antidepressant, the first two weeks are definitely not the period with the most average suffering or negative reactions. read more

There’s a paradoxical period when a person first starts an antidepressant: they may actually begin to feel worse before feeling better. The underlying cause of this phenomenon is a bit of a mystery, but a new study from researchers at Otto-von-Guericke University in Germany explains why this might occur. read more

During the first few weeks' people commonly experience some side effects or feel worse before they begin to feel better. Although the newer Selective serotonin reuptake inhibitors (SSRIs) usually have fewer or less severe side effects than tricyclic antidepressants, various side effects can occur with them all. read more