This question should immediately strike one as a word game. Many puzzles exist in the same category, such as, "Can God eat oatmeal that no one can eat?" Such puzzles are intended to reveal a logical problem with the divine attribute of omnipotence. read more
Assuming God exits, as is generally understood by this term in the West, then of course God can make 2+2=5. All "he" would have to do is create a universe, or place within the universe, with different rules of logic than the universe that is known to humans, in which 2+2=5. read more