The COSMIC database of cancer mutations is a useful resource. Tumor suppressors just need to be broken, so a very large number of mutations can accomplish this, so the same precise mutation is seen less frequently. read more
Two new studies have revealed that mutations in one location can be responsible for several different, unrelated forms of cancer. Cancer is not one disease. "Cancer,” when used ambiguously, refers to the 200 known types of cancer and their subtypes. read more
Sander described such studies as basket or matrix trials, in which patients with different tumor types—for example, breast, ovarian, or colorectal—but similar constellations of genetic alterations, would be treated with the same drug or drugs. read more