Inertial confinement Fusion as has been practical and repeatable (first-time every-time) since 1952 and the Ivy Mike nuclear test. read more
In principle, if you can compress fission or fusion fuels to extremely high densities very small nuclear explosions could be created (tens to hundreds of milligrams of nuclear fuel). Work has been underway for decades to attempt this, the largest such facility is the National Ignition Facility (NIF) at Lawrence Livermore National Laboratory. read more