Can you have celiac disease without the HLA DQ2 & DQ8 genes?

The majority of patients with CD have been found to carry the HLA DQA1*05 and DQB1*02 alleles, which encode the DQ2.5 molecule, and the ... read more

Celiac disease is a genetic condition, which means you need to have the "right" genes to develop it and be diagnosed with it. HLA-DQ2 is one of two main celiac disease genes, and happens to be the most common gene implicated in celiac disease (HLA-DQ8 is the other so-called "celiac gene"). read more

Only about 2-3% of people with one or both of these genes get celiac. And of those with celiac disease, a New York Times blog article says “95 percent of people with celiac disease have genes that include HLA DQ2, and 5 percent have genes with HLA DQ8”. So if you don’t have these genetic markers for it, you likely won’t get celiac. read more