Do amphetamines increase blood dopamine levels?

Their activity at the serotonin receptor varies, with some acting as agonists and others acting as antagonists (Dean et al., 2013). Amphetamines can also block the reuptake of norepinephrine, dopamine, and serotonin. read more

Yes, amphetamine probably increases blood concentration of dopamine. I have no idea why people are saying no. The extra cellular fluid is not totally independent of blood, it is not a different compartment like intercellular fluid. read more

Like cocaine, amphetamines increase the concentration of dopamine in the synaptic gap, but by a different mechanism. Amphetamines are similar in structure to dopamine, and so can enter the terminal button of the presynaptic neuron via its dopamine transporters as well as by diffusing through the neural membrane directly. read more

Low levels of dopamine are associated with lethargy and chronic fatigue. Drugs that increase dopamine levels in the brain are associated with sleeping problems and insomnia. Learning: High dopamine in certain areas of the brain may enhance our ability to learn new things. read more