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Do anti-depressants work?

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More people in the United States are on antidepressants, as a percentage of the population, than any other country in the world. And yet the drugs' efficacy has been hotly debated. read more

Second only to antibiotics, antidepressants are the most commonly prescribed class of medication. To clarify, when I say antidepressant, I mean the most common of many classes of antidepressants—the selective serotonin reuptake inhibitors, or SSRIs, like Prozac, Celexa, Lexapro, Paxil, or Zoloft. read more

Some people start an antidepressant and expect that it will work right away. After all, when you drink a few cups of coffee, or a few glasses of wine, you feel it pretty fast. People naturally expect the same kind of instant results with antidepressants. But that's just not how antidepressants work. read more

Many, many studies of antidepressants can be found in the peer-reviewed literature. The problem is that this has been a prime example of publication bias: Positive studies are likely to be released, with negative ones more likely to be buried in a drawer. read more

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