Do cancer cells enter the quiescent phase of the cell cycle?

Although many cells in the G0 phase may die along with the organism, not all cells that enter the G0 phase are destined to die; this is often simply a consequence of the cell's lacking any stimulation to re-enter in the cell cycle. read more

Q cells undergo in the G0 phase DNA -deletion and diploidization. Responding to differentiation inducers, Q cells step out from G0, re-enter the cell cycle and accomplish necessary rounds of DNA synthesis. read more

RB protein is a regulator of the cell cycle. It binds E2F to prevent transcription of G1/S phase cyclins until the appropriate time in the cell cycle. In this rare cancer, there is a loss of function or deletion of one copy of RB in every cell (defect is inherited). There is still one copy of the good RB gene. read more