They DO need to be launched where they get the greatest boost from the Earth's eastward rotation and can get into the desired orbit with the least additional fuel, so most launch sites are closer to the equator than the poles (where the ozone hole is largest). read more
Yes, rocket exhaust makes holes in the ozone layer. A rocket launched from White Sands NM made a county-sized hole in the ozone layer back in 2000 in the wee hours of the morning, and the Sun healed it shut as soon as UV-C hit that are of the atmosphere. read more