Does a skeletal muscle cell have more than one nucleus?

Yes, a skeletal muscle does have multiple nuclei, or it is multinucleated, as does cardiac muscle. Smooth muscle, however, only has one nucleus per cell, or it is uninucleated. read more

Muscle cells and muscle fibers have many nuclei because these cells arise from a fusion of myoblasts. Before being fused the myoblasts each have their own nucleus. After being fused together, the multiple myoblasts become a muscle fiber that has multiple nuclei. read more

Skeletal muscle fibers are made when myoblasts fuse together;muscle fibers therefore have multiple nuclei (each nucleus originating from a single myoblast). The fusion of myoblasts is specific to skeletal muscle (e.g., biceps brachii) and not cardiac muscle or smoothmuscle. read more