Does phentermine cause sleep disorders?

Phentermine is similar to its parent compound, amphetamine, as they both are TAAR1 agonists. Phentermine works on the hypothalamus in the brain to stimulate the adrenal glands to release norepinephrine, a neurotransmitter that induces the fight-or-flight response, which both reduces hunger and causes insomnia if taken too close to bedtime. read more

" A Randomized, Double-Blind, Placebo-Controlled Study of an Oral, Extended-Release Formulation of Phentermine /Topiramate for the Treatment of Obstructive Sleep Apnea in Obese Adults Conclusions:Phentermine 15 mg plus extended-release topiramate 92 mg induced significant weight reductions and concomitant improvements in OSA and related symptoms vs placebo. read more