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Does the nuclear membrane protect DNA from oxidative stress?

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Although ROS are thought to be a major cause of DNA damage, little is known about the molecular mechanisms protecting nuclear DNA from oxidative stress. read more

However, within 15–30 min after the cells in cultures were exposed to a subtoxic dose of oxidative stress (including IR), many of these proteins concentrated in the nucleus; this suggests that a signaling pathway is induced by oxidative stress that causes transfer of the repair enzymes to the nucleus, which is their site of action . 6. read more

Scientist largely agree that free radicals are the by-products of disease processes, although, in certain pathological conditions, a causative link between free radicals and disease has also been suggested. 2 Irrespective of what comes first, it is now widely recognized that oxidative stress is an important factor associated with many acute and chronic diseases, including: cancer, diabetes, cardiovascular, and neurodegenerative diseases. read more

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