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How do anti-depressants affect the liver?

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Antidepressants may be toxic to the liver, even at recommended doses, and older patients taking multiple prescriptions are most vulnerable. ... In most cases, liver damage is "idiosyncratic and unpredictable, and it is generally unrelated to drug dosage," they say. read more

The other antidepressant my liver doc approved was Effexor because it helps with depression and anxiety and has a short life, and Xanax. I was under the impression most liver docs will work with you re suggesting antidepressants and even have liver-friendly psychiatrists they routinely refer to. read more

Although antidepressants can make bipolar patients manic and they can raise liver counts, these two effects are probably not connected. We are not sure how antidepressants induce mania. Recent studies suggest that people with certain genes are more likely than others to have this problem, and it is not just medications that can do this. read more

Liver problems are not limited to specific doses or specific drugs---any antidepressant at any clinical dose or duration of treatment can cause liver problems or damages, some of which may be long term or serious. read more

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