How do nicotine and acetylcholinesterase inhibitors interact?

Nicotine is an exogenous agonist of nicotinic acetylcholine receptors (nAChR). The acetylcholinesterase inhibitor (AChEi) will stop the functioning of acetylcholinesterase (AChE). read more

Nicotine is an exogenous agonist of nicotinic acetylcholine receptors (nAChR). The acetylcholinesterase inhibitor (AChEi) will stop the functioning of acetylcholinesterase (AChE). To answer your question, I need to preface that it is dose dependent. If there is a low dose of AChEi the nicotine will function as it normally would without the AChEi. read more

AChEIs have relatively few pharmacokinetic interactions, although donepezil and galantamine are metabolized through the liver’s CYP 2D6 and 3A4 pathways. Because rivastigmine does not undergo hepatic metabolism, it is least likely of the cognitive enhancers to have pharmacokinetic interactions with other medications. read more