How do painkillers affect an LSD trip?

I'm assuming that you are referring to opiates when you say “pain killers” here. I doubt that things like aspirin, ibuprofen, or acetominophen (paracetomol) will have much effect either way on an LSD experience. read more

Painkillers usually lessen the effects of LSD from slightly to a considerable amount. They could also add itching, dizziness, nausea and vomiting to the experience. It is possible to be high on both most people would not find it fun. read more

But if you are scared and try LSD or another drug again you could expect psychosis to happen so it happens. So calm yourself down if you want to use drugs the next time. Nothing is going to harm you. read more

Basically, the only medications that will effect your trip are those that affect your serotonin levels in someway (which ibuprofen does not). The only interactions I've ever heard of are (1) SSRIs and other anti-depressants make trips less intense per micro-gram of lsd, (2) taking certain prescription ergot-derived migraine medications while tripping can lead to serotonin syndrome. read more