How does ecstasy use affect the brain?

MDMA affects the brain by increasing the activity of at least three neurotransmitters (the chemical messengers of brain cells): serotonin, dopamine, and ... read more

MDMA affects the brain by increasing the activity of at least three neurotransmitters (the chemical messengers of brain cells): serotonin, 89,90 dopamine, and norepinephrine. 91 Like other amphetamines, MDMA enhances release of these neurotransmitters 89–92 and/or blocks their reuptake, 93,94 resulting in increased neurotransmitter levels within the synaptic cleft (the space between the neurons at a synapse). read more

However, whereas amphetamines primarily affect dopamine levels, ecstasy primarily affects neurons that use serotonin. Serotonin plays a role in sleep, mood, sexual behavior, and anxiety, in case you're not familiar with it. read more