How does Pepto-Bismol affect warfarin?

If you have suffered from an upset stomach, chances are you've reached for the cool chalky relief of something like the Pepto-Bismol® medication, the Kaopectate® drug or any other type of medication that can be labeled as bismuth subsalicylate. read more

Applies to: Coumadin (warfarin), Pepto-Bismol (bismuth subsalicylate) GENERALLY AVOID: Theoretically, salicylates may potentiate the effects of anticoagulants and increase the risk of bleeding. Salicylates interfere with the action of vitamin K and induce a dose-dependent alteration in hepatic synthesis of coagulation factors VII, IX and X, occasionally increasing the prothrombin time. read more

It is not recommended to take Pepto-Bismol with warfarin. The problem is the fact that pesto-bismol has salicylate in it which is known to effect certain clotting factors by interfering with vitamin K. read more

pepto bismol is a medication which contains salicylate and does thin the blood, but it works by a separate mechanism than coumadin does. because coumadin and pepto bismol affect blood clotting in different ways, their effect is additive and could result in potentially serious bleeding. read more