How does the low level of estrogen give rise to osteoporosis?

Estrogen acts on osteoclasts to trigger apoptotic pathways[1]. High levels of estrogen shift the balance towards osteoblasts to promote bone growth. Conversely, estrogen acts to drive the development of osteoblasts[2]. As a result of this, low estrogen levels can cause a weakening of one's bones. Footnotes. read more

Low estrogen levels can lead to increased bone decay and osteoporosis. Estrogen helps to regulate bone cells called osteoblasts, which are responsible for building new bone. When estrogen levels drop, fewer cells are produced and bone is lost, but not replaced. read more

This drug is a selective estrogen receptor modulator (SERM) that “acts” like estrogen. It is approved for prevention and treatment of osteoporosis and can prevent bone loss at the spine, hip, and other areas of the body. Studies have shown that Evista can decrease the rate of vertebral (back) fractures by 30 to 50 percent. read more