They are responsible at muscle contraction level. The nerve impulse arrived at the neuromuscular junction can't cause contraction without sarcoplasmic reticulum (smooth endoplasmid reticulums in muscle fibres involved in storage of calcium). read more
They also help to detoxify the harmful drugs. In some cells SER is responsible for transmission of impulses, e.g muscle cells, nerve cells. It also plays an important role in transport of materials from one part of the cell to the other. Endoplasmic reticulum also provides mechanical support to the cell so that its shape is maintained. read more