How much pure nicotine is lethal?

The lethal dose of pure nicotine is also difficult to determine, because it easily decomposes a bit and, on the other hand, mostly contains more or less water; however, in accordance with the severe symptoms evoked in several experimenters by 0.002–0.004 g it is certainly not going to be higher than 0.06 g. read more

Therefore the new LD50 is applicable only to injected doses since ingestion and inhalation of pure nicotine is extremely unlikely to lead to death in adults: Prof Hajek shows that harm by inhalation is next to impossible, and Prof Mayer shows death by ingestion is simply too difficult to be considered a practical issue, in adults. read more

The LD50 of nicotine is 50 mg/kg for rats and 3 mg/kg for mice. 0.5-1.0 mg/kg can be a lethal dosage for adult humans, and 0.1 mg/kg for children. read more

Chris Price, Practical nicotine applications, author of The Great Nicotine Myth, etc. Updated Feb 26, 2018 · Author has 2.9k answers and 2.8m answer views It takes a significant dose of nicotine for lethality, and for all practical purposes it would have to be injected. read more

Nicotine poisoning describes the symptoms of the toxic effects of nicotine following ingestion, inhalation, or skin contact. Nicotine poisoning can potentially be deadly, though serious or fatal overdoses are rare. Historically, most cases of nicotine poisoning have been the result of use of nicotine as an insecticide. read more