How Warfarin affects Aspirin bioavailability?

Warfarin and aspirin are widely used in a wide spectrum of thromboembolic and atherothrombotic diseases. Despite the potential efficacy of warfarin-aspirin therapy, the safety and side effect of combined therapy remains unclear. 2. read more

Combining warfarin and aspirin increases the risk of bleeding. A review of the evidence reveals scant few groups of patients that enjoy a net clinical benefit from the combination. In patients with mechanical valves, acute coronary syndrome and recent coronary stents, the benefit (embolic prevention) seems to outweigh the burden (bleeding). read more

3. Metronidazole, Trimethoprim-sulfamethoxazole (co-trimoxazole) and Fluconazole decrease metabolism of S-warfarin, increasing its effects. 4. Amiodarone, Disulfiram and Cimetidine decrease metabolism of both S and R warfarin, enhancing the effects. 5. Cholestyramine binds warfarin in intestine and decreases absorption and bioavailability. read more

The major side effect of warfarin use is bleeding. Risk of bleeding is increased if the INR is out of range (due to accidental or deliberate overdose or due to interactions). Many drug interactions can increase the effect of warfarin, also causing an overdose. read more