Well first is it front or rear wheel drive? ~ I know little to nothing of front wheel drive vehicles though surely they are not reversible due to almost certain length differences. read more
Any point of contact can and will generate friction. The tires that contact the road surface - friction. The wheel is attached to a hub, the hub rotates via a bearing. This bearing consists of balls or rollers and races contacting each other - friction. The axles are attached to the hub and also a differential of some sort. read more