Among ordinary people it's unknown. Among academics it depends on areas. History folks know it (my wife's professor knows every corner of Prague). Math folks usually know it (math department has pretty strong connections in academia in the east coast). read more
At the good universities in the United States, the Charles University will be well-known. In some cases, it may in fact be the only university from which the given university will accept people from the Czech Republic. read more
Exhibition “The University and the Republic: 100 Years – 100 Items – 100 Stories” will deal with the relationships between Prague University and the Czechoslovak and Czech Republics based on a hundred exceptional exhibits, each representing one year in the period 1918-2018. read more