Is it possible for domestic rabbits to mate with wild rabbits?

Yes. It is quite common in my area to see wild domestic/wild rabbit crosses. They tend to not have the camouflaging coats that the natives wild rabbits do, but as they tend to be in more urban areas it's not a major impediment to survival. read more

Wild rabbits and domestic rabbits are completely compatible sexually. Once you get past the hair style and color, they're the same critter, much closer than a wolf is to a dog. Risks for the offspring would be color variations that are not the natural camouflage of the wild parent. read more

Just been looking at a site ,( Doing it, when rabbits go at it) , USA, where several domesticated bunnies have escaped. One post says that, quote,"Domestic rabbits are incapable of cross breeding with wild cottontails. read more

Wild rabbits are experts at food foraging in their natural environment, while domesticated rabbits are not and will have a harder time finding food in the wild. In general, wild cottontail rabbits (Sylvilagus spp.) have a lifespan of about one year—possibly three, if they're very, very clever. read more