Is there a safe dose of warfarin?

I have a patient who has maintained an INR (international normalized ratio) of 1.4 to 1.7 after taking warfarin 10 mg daily for 4 weeks. He states he has been eating a lot of green leafy vegetables. How high can I increase the warfarin dose? read more

Well yes there is a safe dose of warfarin, zero mg is safe. Just like anything in life there are consequences of our actions. Instead of looking at the safe doses we start out in the scientific field by looking at the lethal doses in rats/mice and other non-human subjects. read more

It is generally believed that doses between 2 and 10 mg daily will be adequate for most patients. While higher than average, 10 mg per day is not an extraordinarily high dose of warfarin, nor is it an uncomfortably high dose for individuals whose diets are high in vitamin K, such as vegetarians. read more

-Initial dose is influenced by age, race, body weight, gender, concomitant medications, comorbidities, genetic variation, and possibly other factors.-Dosage and administration must be individualized according to the patient's INR and condition being treated. read more