What are negative long term effects of regular cocaine use?

At the same time, circuits involved in stress become increasingly sensitive, leading to increased displeasure and negative moods when not taking the drug, which are signs of withdrawal. ... Tolerance to cocaine reward and sensitization to cocaine toxicity can increase the risk of overdose in a regular user. read more

With regular use, tolerance may develop so that higher doses, more frequent use of cocaine, or both are needed to produce the same level of pleasure and relief from withdrawal experienced initially. 10, 18 At the same time, users can also develop sensitization, in which less cocaine is needed to produce anxiety, convulsions, or other toxic effects. 7 Tolerance to cocaine reward and sensitization to cocaine toxicity can increase the risk of overdose in a regular user. read more

Long term cocaine use is toxic to the brain and to heart muscle so you can get significant stroke (decreased blood from from vasoconstriction) or dilated cardiomyopathy. Stroke can lead to significant morbidity with loss of brain function. Dilated cardiomyopathy will eventually require a heart transplant. read more

The phrase “dope fiend” was originally coined many years ago to describe the negative side effects of constant cocaine use. As tolerance to the drug increases, it becomes necessary to take greater and greater quantities to get the same high. read more