One of the two biggest problems with mixing opioid painkillers like Vicodin or oxycodone with benzodiazepines like Xanax or Valium is the issue of oversedation. read more
Applies to: Valium (diazepam) and oxycodone Using narcotic pain or cough medications together with other medications that also cause central nervous system depression can lead to serious side effects including respiratory distress, coma, and even death. read more
Some users may attempt to mix opioid painkillers (e.g., Vicodin or oxycodone) and benzodiazepines (e.g., Xanax or Valium) in an effort to enhance the painkilling or euphoric effects of opiates. This combination has drawn a great deal of attention due to its potential consequences. read more