What causes kidney failure in humans?

Polycystic kidney disease, a genetic condition where fluid-filled sacs form in your kidneys Defects present at birth can block the urinary tract or affect the kidneys. One of the most common ones involves a kind of valve between the bladder and urethra. read more

Post renal causes of kidney failure (post=after + renal= kidney) are due to factors that affect outflow of the urine: Obstruction of the bladder or the ureters can cause back-pressure because the kidneys continue to produce urine, but the obstruction acts like a dam, and urine backs up into the kidneys. read more

People who are most at risk for kidney failure usually have one or more of the following causes: Loss of blood flow to the kidneys. A sudden loss of blood flow to your kidneys can prompt kidney failure. read more