What could a lethal dose of methadone do to an adult?

The question of how much methadone does it take to overdose can be a complicated one. Officially the lethal dose for an adult who isn't tolerant to methadone is 25 mg., but for someone who uses methadone regularly, the fatal dose may be 200 mg. read more

Lethal means to cause death, so a lethal dose of methadone would kill an adult. A large dose can kill a person who's not opioid tolerant, but a lethal dose of anything means just that, a dose large enough to kill. read more

In children, this minimum lethal dose could be as low as 10mg. For opioid-addicted people, these levels are much higher. In fact, they might take doses of over 100mg each day without any discernible side effects. Combining Methadone with Other Medications. Another way that it’s possible to create a lethal dose of methadone is if you mix it with other medications. read more

-The patient's oral dose should be converted to the parenteral dose based on a 2:1 ratio (e.g., oral methadone 10 mg = parenteral methadone 5 mg)-Injectable products are not approved for the outpatient treatment of opioid dependence. Comments:-Use lower dose for patients whose tolerance is expected to be low at treatment entry. read more