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What do the A, P, E sites stand for in ribosomes?

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The three tRNA-binding sites in ribosomes typically refer to: 1. Aminoacyl-tRNA binding, or A-site 2. Peptidyl-tRNA binding, or P-site 3. read more

tRNA exit site, or E-site Structure of the ribosome: The three tRNAs bound to the ribosome are indicated in magenta (A-site), green (P-site) and yellow (E-site). mRNA is indicated in black. Image source: What recent ribosome structures have revealed about the mechanism of translation. read more

A-site: the ribosomal site most frequently occupied by aminoacyl-tRNA. The aminoacyl-tRNA in the A-site functions as the acceptor for the growing protein during peptide bond formation. P-site: the ribosomal site most frequently occupied by peptidyl-tRNA, i.e. the tRNA carrying the growing peptide chain. read more

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