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What does LSD (the drug) do to your brain?

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There's a reason you feel more connected to the universe on acid, finds a new brain study on lysergic acid diethylamide (LSD) ... What exactly happens to the brain on psychedelic drugs? A ... “Now is the first time we have both fMRI machines and clearance to do experiments with LSD,” Tagliazucchi says. read more

(LSD is illegal in the UK, but it’s possible to use it in research with special permissions.) Once, they were injected with a small amount of LSD (75 micrograms); the other time they received a saline placebo. After an hour, to let the effects settle in, they got into an fMRI brain scanner, which captured images of what went on in their brains. read more

What they do know is that the increase in brain activity, which causes the overactive imagination that many users report, is caused by the serotonin receptors, the brain’s key chemical messengers. There are 15 different serotonin receptors, but LSD specifically activates the 2A subtype (5-HT2A). read more

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