Diploid organisms, such as we are, generally have two copies of each gene (excepting the sex chromosomes in males). In order to display the genotype for each, geneticists use shorthand. When referring to a gene, + means the wildtype, which is the "normal" version, and - means that the gene is missing, often a knockout. read more
So a typical individual's genome for a particular gene will be +/+, a hemizygote (one copy deleted) is +/-, and a complete knockout is -/-. The image is talking about peroxisomes, claiming that they are required for life, specifically the gene Pex5. read more
In order to display the genotype for each, geneticists use shorthand. When referring to a gene, + means the wildtype, which is the"normal" version, and - means that the gene is missing, often a knockout. read more