What goes wrong during the cell cycle in cancer cells?

Through our expertise, Cyclacel is developing cell cycle-based, mechanism-targeted cancer therapies that emulate the body's natural process in order to stop the growth of cancer cells. This approach can limit the damage to normal cells and the accompanying side effects caused by conventional chemotherapeutic agents. read more

The cell cycle, the process by which cells progress and divide, lies at the heart of cancer. In normal cells, the cell cycle is controlled by a complex series of signaling pathways by which a cell grows, replicates its DNA and divides. read more

In our cells we have enzymes called cyclin-dependent kinases (CDKs) that bind to other proteins called cyclins to form an active complex that drives the cell cycle. We have different types of CDKs and cyclins that can form different complexes and drive different phases of the cell cycle. read more

When a cell’s DNA is damaged, a sensor protein activates p53, which halts the cell cycle at the G 1 _1 1 start subscript, 1, end subscript checkpoint by triggering production of a cell-cycle inhibitor. read more