The nucleolus disappears during prophase. In the cytoplasm, the mitotic spindle, consisting of microtubules and other proteins, forms between the two pairs of centrioles as they migrate to opposite poles of the cell. The nuclear envelope disappears at the end of prophase. read more
Prophase is one of the first phases of mitosis and it focuses on preparing the spindles, metaphase plate and chromosomes to work in the later phases of the process. Prophase exists in both mitosis and meiosis. read more