Here's some general route ideas from years of doing the same. Take I-10 West outta Houston. Get some BBQ in Junction, maybe. Stop at Balmorrea state park (TX) and swim if in season. spend the night in a cabin there (make reservations) Consider a detour to Carlsbad Caverns, perhaps White Sands. read more
View a map with the driving distance between Houston, TX and San Francisco, CA to calculate your road trip mileage. read more