Obes Rev. 2007 Jan;8(1):21-34. The role of leptin and ghrelin in the regulation of food intake and body weight in humans: a review. Klok MD(1), Jakobsdottir S, Drent ML. Author information: (1)Department of Endocrinology, VU University Medical Center, Amsterdam, the Netherlands. read more
The role of leptin and ghrelin in the regulation of food intake and body weight in humans: a review. Klok MD(1), Jakobsdottir S, Drent ML. Author information: (1)Department of Endocrinology, VU University Medical Center, Amsterdam, the Netherlands. read more
Leptin is a cell-signalling hormone vital in the regulation of appetite, food intake and body weight. Studies have shown that an absence of leptin in the body or leptin resistance can lead to uncontrolled feeding and weight gain. read more
On the other hand, during fasting or in anorexia nervosa (is a severe psychiatric disorder affecting about 0.9% of women and 0.3% of men characterized by a marked decrease in food intake from self-induced starvation, extreme weight loss, BMI<18.5 kg/m2 and reduced body fat), which entails a lower body fat, leptin is down-regulated 13) while ghrelin is up-regulated 14), 15). read more