What is the maximum dose of metformin?

Dose titration: Increase in 500 mg weekly increments as tolerated. Maintenance dose: 2000 mg daily. Maximum dose: 2500 mg daily. Comments: -Metformin, if not contraindicated, is the preferred initial pharmacologic agent for treatment of type 2 diabetes mellitus. read more

-Elderly, debilitated, and malnourished patients: Titration to the maximum dose is generally not recommended. -Concomitant Insulin therapy: When initiating treatment in patients currently receiving insulin, metformin should be started at 500 mg orally once a day and titrated in 500 mg increments weekly. read more

The recommended starting dosage of both metformin and metformin ER for people taking insulin is 500 mg once daily. The maximum total daily dose for people taking insulin is 2500 mg for metformin and 2000 mg for metformin ER. Usually, when adding metformin to insulin, you should continue with your normal insulin dose. read more