The understanding of the effects of leptin on the glucose-insulin homeostasis will lead to the development of leptin-based therapies against diabetes and other ... It also plays key roles in the regulation of glucose homeostasis and insulin sensitivity, independent of actions on food intake, energy expenditure or body weight. read more
Well adiponectin are produced by adipocyte and have function of lipolysis or breaking down of fat. Despite being produced from adipocytes its level are low in fat people than lean people. read more
Major adipocytokines adiponectin and leptin Adiponectin decreases with increase in the adiposity. Reduction of adiponectin has been associated with insulin resistance, dyslipidemia, and atherosclerosis. Leptin levels increase in obesity. Leptin signal is transmitted by the Janus kinase, signal transducer and activator of transcription ((JAK-STAT) pathway. read more
Reduction of adiponectin has been associated with insulin resistance, dyslipidemia, and atherosclerosis in humans. The other major adipokine is leptin. Leptin levels increase in obesity and subcutaneous fat has been a major determinant of circulating leptin levels. read more