Studies in rodents suggest that a reduction in leptin level during weight loss signals to the brain to increase feeding and decrease energy expenditure. In this issue of the JCI, Rosenbaum et al. read more
Leptin is the 16 kDa hormonal product of the obesity (ob) gene. It is the key element of the central and peripheral signals which are involved in the maintenance of energy homeostasis. It is primarily secreted by adipocytes. read more
Leptin resistance in obesity Leptin interacts with specific leptin receptors to inhibit excess feeding and its elevation and obesity is therefore often thought to indicate a leptin resistant state. Leptin resistance in obese individuals is thought to arise due to a blunted response of leptin to caloric intake. read more
Leptin acts by binding to specific receptors in the hypothalamus to alter the expression of several neuropeptides that regulate neuroendocrine function and energy intake and expenditure. Thus, leptin plays an important role in the pathogenesis of obesity and eating disorders and is thought to mediate the neuroendocrine response to food deprivation. read more