What potentiates methadone?

Coadministration of methadone with CYP inducers of these enzymes may result in a more rapid metabolism and potential for decreased effects of methadone, whereas administration with CYP inhibitors may reduce metabolism and potentiate methadone's effects. read more

A fun little fact first. Methadone was created in 1939 by the Nazis as a replacement for morphine. Hitler wanted a longer acting drug for his soldiers. Methadone has a half-life of around 24-36 hours. Most people think Methadone is strictly a drug made to treat Heroin addicts but Methadone's main purpose is the same as morphine, OxyContin, etc. read more