Which tissues are insulin dependent for glucose uptake?

In brief, * Skeletal muscle accounts for approximately 70% of insulin mediated glucose uptake. * Adipose tissue accounts for about 10% of insulin dependent glucose uptake. read more

Adipose tissue accounts for about 10% of insulin dependent glucose uptake. While intracellular glucose uptake in the liver is not insulin dependent, insulin does modulate key metabolic processes in the liver through signalling cascades. read more

These molecules transport glucose by facilitative diffusion down concentration gradients, in contrast to energy-dependent uptake of glucose in the gut or kidney. Although glucose movement can be bidirectional across the cell membrane, in general -- and particularly in metabolically active insulin-sensitive tissues -- glucose transport proceeds from the exterior to the interior of the cells. read more

Thus, GLUT4 is insulin-dependent and mediates the insulin-stimulated glucose disposal in muscle tissue. GLUT1 protein may be responsible, at least in part, for the constitutive, insulin-independent glucose uptake in all cells including muscle . In addition to its traditional role, muscle tissue has other functions, such as a role in immunology. read more