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Why are cholesterol levels elevated in nephrotic syndrome?

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Both increased synthesis and decreased clearance of lipoproteinemia may contribute to the hyperlipoproteinemia which frequently complicates the nephrotic syndrome with increased levels of total and low-density lipo-protein (LDL) cholesterol as the most characteristic abnormality. read more

But for Nephrotic Syndrome patients, their kidneys can not retain the protein in the body, as a result, a lot protein leaks into the urine, which can promote the synthesis of lipoprotein in the liver so as to increase high blood cholesterol. read more

So in this war,the LDL wins and so that is how cholesterol levels increase in the blood in nephrotic syndrome. (These lipoproteins -HDL and LDL are the ones that carry the cholesterol in the blood. HDL carries it into the liver thus reducing its level in the blood. read more

Marked hypercholesterolemia is common in patients with the nephrotic syndrome: Among 207 adults with nephrotic syndrome due to nondiabetic renal disease (mean proteinuria 7.2 g/24 hours), the mean total cholesterol concentration was 302 mg/dL (7.8 mmol/L) . read more

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