The same reason why we are afraid of serial killers and rapists. They are very unpredictable and have no morals or sympathy where as you know how you're fellow civilized humans think and act. read more
Animals that are not afraid of predators are dead animals, hence have no offspring, hence the proportion of animals that are not afraid decreases to the point where there are practically none of them left (at least wild animals). read more
Humans can kill at a distance. A wolf standing some distance away from a deer is a threat, but it's not an immediate threat. The deer may be better off staying where it is and just keeping an eye on the wolf. read more
One reason is philosophical: Some feel that while humans have duties to treat well the animals that they use or live with, they have no responsibility to those outside their sphere of interaction. read more