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Why aren't dopamine injections given to Parkinson patients?

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The problem in Parkinsonism can be looked at in two ways: Dopamine deficiency or Acetyl Choline excess, since normally there is a balance between the two. And, therapies targetting any of these neurotransmitter systems is useful. read more

Anticholinergics are especially useful to treat drug induced Parkinsonism (for example a patient on antipsychotics like Haloperidol, that helps by blocking the excess Dopamine that is present in the mesolimbic pathway of these patients also blocks the dopamine receptors in the nigro-striatal pathway thus precipitating Parkisonism that cannot be treated using Dopamine agonists, which, by the way, will be bad for the psychosis). read more

Dopamine Agonists in Parkinson's Disease. There are a few dopamine agonists like: (Mirapex) Pramipexole (Requip) Ropinirole (Neupro) Rotigotine All of these medications mimic the effects of dopamine at selected dopamine receptors, which are cells that enhance the effects of dopamine in the brain. read more

Some of the older dopamine agonists increase the risk of heart problems. As a group, these are known as the ‘ergot’ types and they include bromocriptine, pergolide and cabergoline. Because of this risk, these Parkinson’s drugs are not commonly used. All newer dopamine agonists are non-ergot in type. read more

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