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Why aren't there lymph nodes in the brain?

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Brain was considered as one of the immunologically privileged sites. Although there are macrophages called Microglia in the brain, lymphocytes usually need to cross the blood-brain-barrier to get into the brain. I think there are two major reasons why lymph nodes are not in the brain: Brain is rarely a place for pathogen entry. read more

After all, other solid organs such as the heart and kidneys don’t have lymph nodes inside them either. Even so, the brain has a totally different relationship to lymphatics. read more

Scientists found that the brains of mice contain lymph vessels that can carry fluid and immune cells from cerebrospinal fluid. Problems in this system might play a role in neurological disorders. Scientists found that the brains of mice contain lymph vessels that can carry fluid and immune cells from cerebrospinal fluid. read more

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