There continued to be major outbreaks of the plague until 1720, so that the disease was not completely eradicated until much later. However, the outbreaks were never as virulent as that of the Late Middle Ages. Effects and consequences. The disease had a terrible impact. read more
Bubonic Plague and Cholera were the top two pandemics, both having visited (at that time) the world’s largest city several times. Such pandemics were brought to an end by the last half of the 19th century, roughly 100 years before antibiotics, and roughly 40 years before medicine recognized microbes as the agents of these diseases. read more