You meant (Witchcraft) or casting a spell on him may be. Well, this had never been mentioned to be the reason why Mohammad (PBUH) left Mecca to Medina in what is known as the second (Hijrah) or migration . read more
According to the Islamic faith, the Prophet was commanded by Allah to leave Mecca for Medina. The plot to assassinate him was the result of his preaching of the revelations God bestowed upon him. He could not preach in public and he had several opponents and enemies in Mecca. read more
Muhammad left Mecca, in 622 CE, after he was warned about a plot to assassinate him. The migration of the Prophet and his followers from Mecca to Medina is known as Hijra or Hegira. read more